Glomus tumor of the thigh mimicking nerve sheath tumor: A report of two cases and review of literature

Background: Glomus tumors are uncommon benign tumors most commonly found in the subungual areas of the digits. Extradigital glomus tumors are rare and often present with nonspecific symptoms, which prolongs patient suffering and delays diagnosis. Case Description: We report two cases of glomus tumors located in the thigh; each associated with chronic, focal pain that went undiagnosed for several years. Both patients underwent extensive evaluations and failed multiple conservative treatments before surgical excision. Surgical resection resulted in complete symptom resolution. Conclusion: These cases demonstrate the difficulty in diagnosing extradigital glomus tumors and emphasize the importance of maintaining a broad differential for small tumors of the extremities and unexplained limb pain. Early imaging and interdisciplinary awareness are essential to reduce delays in diagnosis and ensure timely and curative treatment.