Cobalt-Catalyzed Three-ComponentSynthesis of Sulfoximine-ContainingGuanidines: Retention of the High-Valent S(VI) Sulfoximine Motif
Abstract We have developed a cobalt(II)-catalyzed three-component coupling of sulfoximines, isocyanides, and sulfonyl azides for the synthesis of sulfoximine-containing guanidines. The method features operational simplicity, broad substrate applicability, and good functional group tolerance. In this work, “protection” refers to retention of the high-valent S(VI) sulfoximine motif during guanidine construction rather than introduction of a conventional removable protecting group.
Authors
- Yu-Xiao Ding
- Shun‐Yi Wang (ORCID: https://orcid.org/0000-0002-8985-8753)
- Weidong Rao (ORCID: https://orcid.org/0000-0002-6088-7278)
- Syed Anis Ali Shah
- Daopeng Sheng
- Jing-Han Peng (ORCID: https://orcid.org/0000-0003-4202-6471)
- Kai Liu
- Gang Wang
Institutions
- Nanjing Forestry University (CN)
- Soochow University (TW)
- Sanjiang University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-08-14
- DOI
- https://doi.org/10.1021/acs.joc.6c01291
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cyrus Tang Foundation
- National Natural Science Foundation of China
- Soochow University
- Priority Academic Program Development of Jiangsu Higher Education Institutions