Successful Non-surgical Treatment for a Duodenal Perforation Caused by the Rupture of an Intraductal Papillary Mucinous Neoplasm of the Pancreas

An intraductal papillary mucinous neoplasm (IPMN) was incidentally detected in a 91-year-old woman 12 years before her current admission. The patient declined additional examinations and surgical intervention. Over the subsequent years, she experienced recurrent acute pancreatitis and ultimately developed a gastrointestinal perforation due to the rupture of the IPMN. Considering her age, general condition, and personal wishes, conservative management was selected, which allowed her to successfully resume oral intake until death from cancer. This rare clinical course provides valuable insights into the management of older adults with IPMN, a condition that is likely to be frequently encountered as the population ages.

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Journal
Internal Medicine
Published
2026-08-14
DOI
https://doi.org/10.2169/internalmedicine.6315-25
Primary Topic
Pancreatic and Hepatic Oncology Research
Type
article
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article

Successful Non-surgical Treatment for a Duodenal Perforation Caused by the Rupture of an Intraductal Papillary Mucinous Neoplasm of the Pancreas

Keiichi Ito, Hiroaki Koike, Kohzoh Makita, Akira Miyazaki
Internal Medicine
Pancreatic and Hepatic Oncology Research
article

Successful Non-surgical Treatment for a Duodenal Perforation Caused by the Rupture of an Intraductal Papillary Mucinous Neoplasm of the Pancreas

Keiichi Ito, Hiroaki Koike, Kohzoh Makita, Akira Miyazaki
article en

Abstract

An intraductal papillary mucinous neoplasm (IPMN) was incidentally detected in a 91-year-old woman 12 years before her current admission. The patient declined additional examinations and surgical intervention. Over the subsequent years, she experienced recurrent acute pancreatitis and ultimately developed a gastrointestinal perforation due to the rupture of the IPMN. Considering her age, general condition, and personal wishes, conservative management was selected, which allowed her to successfully resume oral intake until death from cancer. This rare clinical course provides valuable insights into the management of older adults with IPMN, a condition that is likely to be frequently encountered as the population ages.

Internal MedicineVol. 65(16)
Nerima General Hospital (JP), Nikko Memorial Hospital (JP), Midorigaoka Hospital (JP)
Good health and well-being
Openalex Percentile: Top 12%
Pancreatic and Hepatic Oncology Research
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