Validation in Adult Black and White Women of the ISS Model for Estimating Insulin Sensitivity and Beta-Cell Function from Mixed Meal Tests

The ISS (Insulin Secretion and Sensitivity) differential equation model has been previously shown to provide simultaneous estimates of SI and BCF during an oral glucose tolerance test. Using the Federal Women's Study, we adapted the ISS model to fit glucose and insulin dynamics and estimate SI and BCF during mixed meal tests. Our goal was to develop an effective, straightforward, and reliable tool that would be simpler to use than currently available approaches that require technically challenging deconvolution methods to assess BCF. The ISS model for mixed meal tests strongly correlated with oral glucose tolerance tests and gold-standard estimates from intravenous glucose tolerance tests and were reliable when using a shortened 2-hour MMT protocol. The ISS model is versatile, publicly available, and expands the toolbox for assessing post-prandial glucose-insulin homeostasis.