Prevalence and Clinical Impact of Large Vessel Disease in Patients With CADASIL
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), caused by NOTCH3 pathogenic variants, is the most prevalent hereditary small vessel disease. While primarily affecting penetrating arteries, the clinical significance of concomitant large vessel disease (LVD) remains uncertain. We investigated LVD prevalence, its correlation with neuroimaging markers, and its role in predicting previous and incident stroke.
Authors
- Sung‐Chun Tang (ORCID: https://orcid.org/0000-0003-3731-5973)
- Miao‐Jen Kuo
- Ying‐Chi Shen (ORCID: https://orcid.org/0000-0002-0103-7572)
- Chih‐Hao Chen (ORCID: https://orcid.org/0000-0002-1258-8775)
- Yu‐Wen Cheng (ORCID: https://orcid.org/0000-0002-3054-6333)
- Kuan‐Lin Sung (ORCID: https://orcid.org/0000-0002-3354-7120)
Institutions
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
- National Taipei University (TW)
Publication Details
- Journal
- Neurology Open Access
- Published
- 2026-08-14
- DOI
- https://doi.org/10.1212/wn9.0000000000000154
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science and Technology Council