Ir(III)-Catalyzed Carbonylative Cyclization of 2-AlkenylAnilines via <i>Ex Situ</i> Generation of CO: Access to2-Quinolone Derivatives

Abstract Herein, we describe a novel method for the synthesis of 2-quinolones through Ir(III)-catalyzed carbonylative cyclization of 2-alkenyl anilines. The use of Mo(CO)6 as a CO surrogate, together with a two-chamber reactor system, enables safe and efficient access to these compounds. Experimental and computational mechanistic investigations guided the rational development of this transformation. The synthetic potential of this method is further demonstrated by the synthesis of bioactive compounds.