Metal‐Free Synthesis of Oxindole‐Based Sulfones via 1,4‐Cyano Migration/Cyclization Through Radical SO <sub>2</sub> Insertion
Oxindole‐based sulfones are privileged structures found in bioactive compounds and natural products. Herein, a three‐component reaction of unactivated alkenes, potassium metabisulfite, and aryldiazonium tetrafluoroborates has been developed to access oxindole‐based sulfones through a 1,4‐cyano migration/cyclization process. Mechanistic studies indicate that the reaction proceeds through a radical pathway and confirm the intermediacy of aryl, sulfonyl, and iminyl radicals.
Authors
- Jie Wu (ORCID: https://orcid.org/0000-0002-0967-6360)
- Wei Peng
- Gang Liu
- Wei Xiao
- Jiaying Mi
Institutions
- Chinese Academy of Sciences (CN)
- Jiangxi Science and Technology Normal University (CN)
- Shanghai Institute of Organic Chemistry (CN)
- Henan Normal University (CN)
- Taizhou University (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2026-08-13
- DOI
- https://doi.org/10.1002/adsc.70711
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00