Research progress on the effect of sericin on bone regeneration

Sericin is a waste material from the silk production process, researchers its found to have good biological activity and is widely used in tissue engineering. The aim of this paper is to summarize the biological applications of sericin in the field of bone tissue engineering and their research progress. Randomized controlled trials, prospective or retrospective clinical studies, case series and reports, and systematic evaluations. MEDLINE, PubMed, and Google Scholar were searched using keywords. Sericin, has the ability to promote cell proliferation and angiogenesis. It also has excellent bone regenerative properties such as promoting osteoblast differentiation. Sericin itself has excellent physicochemical properties and can be processed into materials with different properties for bone regeneration engineering. Bone defects due to various skeletal diseases or surgical needs, etc are a major challenge for clinical treatment. Modern tissue engineering using synthetic osteogenic active materials offers another therapeutic option for bone defects, and sericin is expected to play a greater role as a promising biological material.