A little-known perspective on the I-squared statistic

The I-squared statistic has become hugely popular in meta-analysis. Motivated by the recent statement that 'Informally, it can be considered to reflect the extent to which confidence intervals displayed in a forest plot do not overlap with each other', this short note formalises this perspective. The insights provided by our analysis lend further weight to the interpretation of the I-squared statistic as a measure of inconsistency. This perspective reminds us that visual inspections of forest plots are vitally important when assessing between-study variation.

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Journal
Research Synthesis Methods
Published
2026-11-03
DOI
https://doi.org/10.1017/rsm.2026.10125
Primary Topic
Meta-analysis and systematic reviews
Type
article
Field-Weighted Citation Impact
0.00
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article

A little-known perspective on the I-squared statistic

Julian P. T. Higgins, Dan Jackson, José A López-López
1 links
Research Synthesis Methods
Meta-analysis and systematic reviews
article

A little-known perspective on the I-squared statistic

Julian P. T. Higgins, Dan Jackson, José A López-López
article en

Abstract

The I-squared statistic has become hugely popular in meta-analysis. Motivated by the recent statement that 'Informally, it can be considered to reflect the extent to which confidence intervals displayed in a forest plot do not overlap with each other', this short note formalises this perspective. The insights provided by our analysis lend further weight to the interpretation of the I-squared statistic as a measure of inconsistency. This perspective reminds us that visual inspections of forest plots are vitally important when assessing between-study variation.

Research Synthesis Methods
AstraZeneca (United Kingdom) (GB), University of Bristol (GB), Universidad de Murcia (ES)
Openalex Percentile: Top 46%
Meta-analysis and systematic reviews
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