<i>N</i> <sup>1</sup> ‐Alkylation of Benzotriazoles via Visible‐Light‐Promoted Alkyne–Carbonyl Metathesis
Herein, we describe a photocatalyst‐ and additive‐free three‐component reaction that enables regioselective N 1 ‐alkylation of benzotriazoles. Under visible light irradiation, alkynes and benzoquinones generate para‐quinone methide intermediates in situ, which undergoes subsequent 1,6‐conjugate additions with benzotriazoles. The reaction features mild and efficient conditions, proceeds under light alone, and delivers the alkylated benzotriazoles in up to 98% yield with broad substrate compatibility (34 examples).
Authors
- Bao Qiong Li
- Zhe Dong (ORCID: https://orcid.org/0000-0001-9714-1069)
- Xiang‐Zhi Zhang (ORCID: https://orcid.org/0000-0003-0631-0758)
- Jin-Rong Niu
- Jun-Hui Luo
- Xue Huang
- Xiao‐Huo Chen
Institutions
- Southern University of Science and Technology (CN)
- Wuyi University (CN)
- Wuyi University (CN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2026-08-13
- DOI
- https://doi.org/10.1002/ejoc.70743
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Wuyi University
- Department of Education of Guangdong Province