EBV-driven Gate–License–Amplify circuit in multiple sclerosis pathogenesis
Five recent publications establish a “Gate–License–Amplify” circuit that mechanistically links Epstein–Barr virus (EBV) infection and genetic risk (HLA-DR15) to the pathogenesis of multiple sclerosis (MS). 1 , 2 , 3 , 4 , 5 This new model reveals how EBV reprograms immunopeptidomes to trigger CNS autoimmunity, providing a molecular rationale for the efficacy of B-cell depletion and supporting EBV-directed prevention as a realistic goal.
Authors
- Xiaofei Shi (ORCID: https://orcid.org/0000-0001-6934-5427)
- Qian Zhong (ORCID: https://orcid.org/0000-0003-1071-6996)
- Mu‐Sheng Zeng (ORCID: https://orcid.org/0000-0003-3509-5591)
- Yuxin Li (ORCID: https://orcid.org/0009-0004-4928-3379)
- Wanli Liu (ORCID: https://orcid.org/0000-0003-0395-2800)
- Yuxiao Zhang
Institutions
- Sun Yat-sen University (CN)
- King Center (US)
- Digital Science (United States) (US)
- First Affiliated Hospital of Henan University of Science and Technology (CN)
- Sun Yat-sen University Cancer Center (CN)
- Center for Life Sciences (CN)
- Nanjing University (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Signal Transduction and Targeted Therapy
- Published
- 2026-08-14
- DOI
- https://doi.org/10.1038/s41392-026-02792-4
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Tsinghua University
- Natural Science Foundation of Beijing Municipality