Using the simple telegraph model to decipher transcriptional burst regulation across genome-wide data.
). Their interdependent dysregulation accelerated HCM. This study establishes the simple telegraph model as a scalable framework linking transcriptional burst dynamics to cell fate and pathology.
Authors
- Chengkai Yang
- Sijia Fang
- Guozhi Jiang (ORCID: https://orcid.org/0000-0002-2795-714X)
- Yu Liao (ORCID: https://orcid.org/0009-0004-0774-2741)
- Hongkun Zhang
- Liang Chen
- Yuwen Wu
- Jianshe Yu
- Yueheng Wu
- Feng Jiao
Institutions
- Sun Yat-sen University (CN)
- Guangzhou University (CN)
- Shenzhen Bay Laboratory (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2026-08-21
- DOI
- https://doi.org/10.1016/j.isci.2026.117127
- Primary Topic
- Gene expression and cancer classification
- Type
- article
- Field-Weighted Citation Impact
- 0.00