Therapeutic remodeling of the tuberculosis granuloma with 1-methyl-D-tryptophan enhances CD8<sup>+</sup> T cell-macrophage interactions.
T cell infiltration and reduces T cell activation and proliferation; and iii) therapeutic strategies, including D-1MT, that improve intragranulomatous killing hold strong translational potential.
Authors
- Annu Devi (ORCID: https://orcid.org/0000-0002-4481-4175)
- Deepak Kaushal (ORCID: https://orcid.org/0000-0003-3521-1257)
- Alea Delmastro (ORCID: https://orcid.org/0000-0002-7959-3165)
- Bindu Singh (ORCID: https://orcid.org/0000-0003-2974-1737)
- Caden W. Munson
- Shabaana A Khader
- Erin F McCaffrey
- Nadia A Golden
- Priyanka
- Michael Angelo
- Smriti Mehra
Institutions
- Tulane University (US)
- Texas Biomedical Research Institute (US)
- University of Chicago (US)
- National Institute of Allergy and Infectious Diseases (US)
- Stanford University (US)
Publication Details
- Journal
- PubMed
- Published
- 2026-08-18
- DOI
- https://doi.org/10.1073/pnas.2528104123
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00