Segmental Pallor and Hair Loss in a Patient With Ross Syndrome: Case Report

A 30-year-old male sought medical consultation due to sudden anisocoria. Clinical examination confirmed Adie's tonic pupil. Subsequently, the presence of segmental anhidrosis with compensatory hyperhidrosis and areflexia established the diagnosis of Ross syndrome. In a 15-year follow-up, uncommon manifestations developed in the facial territory affected by compensatory hyperhidrosis: unilateral facial pallor and alopecia following a midline-defined pattern. This case emphasizes the importance of recognizing neurocutaneous manifestations in dermatology practice and suggests that Ross syndrome may encompass a broader spectrum of dermatological findings than currently recognized.

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Publication Details

Journal
The Journal of Dermatology
Published
2026-08-03
DOI
https://doi.org/10.1111/1346-8138.70444
Primary Topic
Sympathectomy and Hyperhidrosis Treatments
Type
article
Field-Weighted Citation Impact
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article

Segmental Pallor and Hair Loss in a Patient With Ross Syndrome: Case Report

Francisco Alejandro Silva Navarro, Ana María Sierra Valiente, Markus Augusto Martínez Holst, Paola Picazo León et al.
The Journal of Dermatology
Sympathectomy and Hyperhidrosis Treatments
article

Segmental Pallor and Hair Loss in a Patient With Ross Syndrome: Case Report

Francisco Alejandro Silva Navarro, Ana María Sierra Valiente, Markus Augusto Martínez Holst, Paola Picazo León, Frida Aguilera Villa, Carolina De La Paz Cruz
article en

Abstract

A 30-year-old male sought medical consultation due to sudden anisocoria. Clinical examination confirmed Adie's tonic pupil. Subsequently, the presence of segmental anhidrosis with compensatory hyperhidrosis and areflexia established the diagnosis of Ross syndrome. In a 15-year follow-up, uncommon manifestations developed in the facial territory affected by compensatory hyperhidrosis: unilateral facial pallor and alopecia following a midline-defined pattern. This case emphasizes the importance of recognizing neurocutaneous manifestations in dermatology practice and suggests that Ross syndrome may encompass a broader spectrum of dermatological findings than currently recognized.

The Journal of Dermatology
Universidad Anáhuac (MX)
Good health and well-being
Openalex Percentile: Top 9%
Sympathectomy and Hyperhidrosis Treatments
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