The Unified Mechanical Model of Neurotransmission: A Theoretical Framework and Experimental Blueprint for Validation

This work presents a revolutionary theoretical framework and a detailed experimental blueprint designed to validate the "Unified Mechanical Model of Neurotransmission." The model posits that the neural signal is primarily carried by a mechanical Action Pressure Wave (APW) generated at the axon hillock, while electrical action potentials (sodium and calcium-based) are secondary facilitatory byproducts. These byproducts prime the axoplasm—by transiently disaggregating neurofibrils and aligning polar molecules—to minimize energy scattering and maximize the mechanical wave's transmission efficiency. The blueprint emphasizes the "golden test," which demonstrates that the mechanical pressure change at the Nodes of Ranvier temporally precedes the electrical charge shift, offering clearly falsifiable predictions at critical sites including the hillock, soma, and terminal bouton. Furthermore, the model provides cohesive physical explanations for the positive correlation between conduction velocity, axon diameter, and myelin thickness, as well as the sealed, hermetically enclosed environment of the axon that makes it an ideal conduit for pressure wave propagation. This research invites simultaneous, high-frequency pressure and charge recording experiments, with a clear classification of predictions into core (whose failure would falsify the hypothesis) and supportive (which would strengthen the model). It opens new horizons for understanding the physical foundations of brain function, moving beyond the conventional electrochemical paradigm.