Meta‐analysis finds ketamine infusions efficacious in treatment of depression

A systematic review and meta‐analysis encompassing 26 ran‐domized controlled trials (RCTs) has concluded that both single and repeated infusions of ketamine significantly improve suicidality and depressive symptoms in patients with a major depressive episode. Most of the serious adverse events that were reported in the included trials were determined to be unrelated to study treatment.

Publication Details

Journal
The Brown University Psychopharmacology Update
Published
2026-08-03
DOI
https://doi.org/10.1002/pu.31487
Primary Topic
Treatment of Major Depression
Type
article
Field-Weighted Citation Impact
0.00
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article

Meta‐analysis finds ketamine infusions efficacious in treatment of depression

The Brown University Psychopharmacology Update
Treatment of Major Depression
article

Meta‐analysis finds ketamine infusions efficacious in treatment of depression

article en

Abstract

A systematic review and meta‐analysis encompassing 26 ran‐domized controlled trials (RCTs) has concluded that both single and repeated infusions of ketamine significantly improve suicidality and depressive symptoms in patients with a major depressive episode. Most of the serious adverse events that were reported in the included trials were determined to be unrelated to study treatment.

The Brown University Psychopharmacology UpdateVol. 37(9)
Good health and well-being
Openalex Percentile: Top 11%
Treatment of Major Depression
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