Cold snare polypectomy for 5-9mm small-bowel polyps in patients with Peutz-Jeghers syndrome by double-balloon enteroscopy: a prospective clinical trial

AIMS: Evaluating the feasibility of cold snare polypectomy (CSP) for small-bowel polyps in patients with Peutz-Jeghers syndrome (PJS). METHODS: PJS patients aged 8-60 years were prospectively enrolled. Small-bowel polyps measuring 5-9mm of the stubby/wide pedicle or sessile type were resected using CSP. RESULTS: Forty patients with 187 target polyps were included. Median size 6 mm and mean polypectomy time 66.4±46.6s. Immediate bleeding rate was 5.9%, with bleeding polyps significantly larger (8mm vs 6mm, P < 0.001). No perforation or delayed bleeding occurred. CONCLUSION: CSP is feasible and safe for 5-9 mm small-bowel polyps in PJS patients.