Structural Characterization of New 8,17-Epoxybriarane Diterpenoids from the Octocoral <i>Briareum stechei</i>
An encrusting, algae-associated octocoral, Briareum stechei, afforded three 8,17-epoxybriarane diterpenoids, including the known compound briaexcavatolide B (1) and two previously undescribed analogues, briastecholides Q (2) and R (3). The absolute configuration of 1 was established for the first time by single-crystal X-ray diffraction analysis. The planar structures and relative configurations of 2 and 3 were determined through extensive spectroscopic analyses. In bioactivity evaluation, compound 2 exhibited cytotoxic effects toward the human acute lymphoblastic leukemia cell lines Molt-4 and CCRF-CEM.
Authors
- Mingzi M. Zhang (ORCID: https://orcid.org/0000-0002-1213-3340)
- Jih‐Jung Chen (ORCID: https://orcid.org/0000-0002-5680-9533)
- Yu‐Jen Wu (ORCID: https://orcid.org/0000-0002-8816-4725)
- Lun K. Tsou (ORCID: https://orcid.org/0000-0002-1593-5226)
- Mei‐Chin Lu (ORCID: https://orcid.org/0000-0003-4335-3837)
- Jyh‐Horng Sheu (ORCID: https://orcid.org/0000-0002-1216-5991)
- Su‐Ying Chien (ORCID: https://orcid.org/0009-0008-0931-3149)
- Yuan‐Bin Cheng (ORCID: https://orcid.org/0000-0001-6581-1320)
- C. H. Hsu
- Liu-Guo Zheng
- Yuan-Hao Liu
- Zhi-Hong Wen
- Ping-Jyun Sung
- Shih-Hsiung Lin
Institutions
- Fu Jen Catholic University (TW)
- National Sun Yat-sen University (TW)
- National Yang Ming Chiao Tung University (TW)
- Kaohsiung Medical University (TW)
- National Health Research Institutes (TW)
- China Medical University (TW)
- National Dong Hwa University (TW)
- TaiGen Biotechnology (Taiwan) (TW)
- Kaohsiung Armed Forces General Hospital (TW)
- National Museum of Marine Biology and Aquarium (TW)
- China Medical University Hospital (TW)
- Institute of Chemistry, Academia Sinica (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- Chemical and Pharmaceutical Bulletin
- Published
- 2026-08-03
- DOI
- https://doi.org/10.1248/cpb.c26-00274
- Primary Topic
- Marine Sponges and Natural Products
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Sun Yat-sen University
- Sun Yat-sen University
- Kaohsiung Armed Forces General Hospital
- National Science and Technology Council