Adjunctive antipsychotics for MDD differ in efficacy and acceptability
A systematic review and network meta‐analysis has found considerable differences in efficacy and acceptability among atypical antipsychotics used as adjunctive treatment for major depressive disorder (MDD). Lumateperone had the greatest effect size for efficacy, and aripiprazole had the highest level of acceptability. Results of the systematic review and meta‐analysis were published online May 6, 2026 in JAMA Psychiatry .
Publication Details
- Journal
- The Brown University Psychopharmacology Update
- Published
- 2026-08-03
- DOI
- https://doi.org/10.1002/pu.31485
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00