Integrative computational and experimental approach identifies PTGS2 as a candidate molecular target in aristolochic acid-induced kidney injury
, AAI exposure caused renal dysfunction and histopathological alterations accompanied by reduced PTGS2 expression. These findings identified PTGS2 as a candidate molecular target involved in AA-induced kidney injury and provided a foundation for further mechanistic research.
Authors
- Shujun Shi
- Ziyi Li (ORCID: https://orcid.org/0000-0001-8815-5696)
- Jianqin Wang (ORCID: https://orcid.org/0000-0003-4020-2494)
- Xiaochun Zhou (ORCID: https://orcid.org/0009-0005-9903-2807)
- Rongrong Deng
- Zhendong Tian
- Xuezhen Ma
- Li Huang
- Jiangwei Man
- Heping Niu
Institutions
- Lanzhou University Second Hospital (CN)
- Gansu Provincial Center for Disease Control and Prevention (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Drug and Chemical Toxicology
- Published
- 2026-07-30
- DOI
- https://doi.org/10.1080/01480545.2026.2704880
- Primary Topic
- Nephrotoxicity and Medicinal Plants
- Type
- article
- Field-Weighted Citation Impact
- 0.00