A New Mechanism of ox-LDL-Induced Endothelial Cell Pyroptosis
Endothelial cell pyroptosis is a key factor promoting plaque instability in atherosclerosis (AS). Serum/Glucocorticoid Regulated Kinase 1 (SGK1) is upregulated in AS, but its upstream regulatory mechanisms and role in pyroptosis remain unclear. This study aims to elucidate the mechanism of action of the GATA Binding Protein 3 (GATA3)/SGK1 axis in ox-LDL-induced endothelial cell pyroptosis.
Authors
- Ping Lü (ORCID: https://orcid.org/0000-0002-3787-4495)
- Xingchun Mo (ORCID: https://orcid.org/0009-0003-9673-6759)
- Xiaojing Yang
Institutions
- Jining First People's Hospital (CN)
Publication Details
- Journal
- International Heart Journal
- Published
- 2026-07-30
- DOI
- https://doi.org/10.1536/ihj.25-615
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00