C-Myc Inhibition Using 10058-F4 Suppressed Ischemia Reperfusion Induced Cardiac Microvascular Endothelial Cell Pyroptosis through the Sam68/NF-κB Pathway
Over the past few decades, most cardiac reperfusion research has focused on the pathogenesis of myocardial ischemia reperfusion injury (MIRI), while little attention has been paid to microvascular ischemia reperfusion (I/R) injury, and few strategies have been available to reverse this pathological process. c-Myc, a proto-oncogene, is related to cardiomyocyte apoptosis and inflammation. It has been reported that Sam68 is involved in inflammatory disorders. However, whether c-Myc and Sam68 can modulate pyroptosis in cardiac microvascular endothelial cells (CMECs) remains unknown.
Authors
- Yonggang Cao (ORCID: https://orcid.org/0000-0002-4021-1422)
- Tianzhu Zhang (ORCID: https://orcid.org/0000-0002-4439-4334)
- Man Jiang (ORCID: https://orcid.org/0009-0008-4609-8222)
- Yongsheng Liu
- Qianhui Zhang
- Peng Wang
- Jianfa Wang
- Hanping Qi
- Hongli Sun
- Qianlong Zhang
- Pilong Shi
- Rui Wu
Institutions
- Jiamusi University (CN)
- Harbin Medical University (CN)
- Daqing City People's Hospital (CN)
- National Quality Inspection and Testing Center for Surveying and Mapping Products (CN)
- Heilongjiang Bayi Agricultural University (CN)
- Chongqing Medical and Pharmaceutical College (CN)
Publication Details
- Journal
- International Heart Journal
- Published
- 2026-07-30
- DOI
- https://doi.org/10.1536/ihj.25-389
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Postdoctoral Science Foundation