AION — Algebraic Interval Ontology for Clinical Networks (FM-3)

AION (Algebraic Interval Ontology for Clinical Networks) is a fully general formal mathematical model of clinical information systems, containing FM-1 as a special case and extending it in all dimensions. Extensions include: a type system with type hierarchy and schema inheritance for arbitrary clinical event types; a universal event model covering examinations, therapies, diagnoses, and observations as typed, attributed time-interval events; a complete temporal relation algebra (all 13 Allen relations); a hierarchical process model with directed acyclic graphs (DAGs); an extended formal query language with temporal quantifiers, cohort combination and multi-patient relations; a causal model with do-operator and counterfactual queries; FHIR mapping as a structural homomorphism; a formal AI layer model; and federation with Differential Privacy guarantees. The reference implementation is available as the Python package aion-clinical on PyPI. NOT a medical device (EU MDR 2017/745 / MPDG). Version 1.2 corrects four findings from an external mathematical review (errata E-4–E-7): the sign in P(precedes), the distributional assumption of the probabilistic Allen relations, the second unit indicator of the contact duration, and the notation of counterfactual queries. In addition: a formal m-nearest-neighbour definition of the matching operator, heuristic labelling of the Shapley back-propagation, and an NP-hardness note on sufficient explanations. Lizenz: Dieses Dokument steht unter AGPL-3.0-only. Alternativ ist eine kommerzielle Lizenzierung durch die ISCaD GmbH auf Anfrage über [email protected] verfügbar. Version 1.3: Lizenz-Restfundstellen (nun durchgängig AGPL-3.0-only) und Software-URL (fm2-project/cairn → iscad/aion) korrigiert, Erratum E-8. Keine inhaltliche Änderung.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-07-30
DOI
https://doi.org/10.5281/zenodo.21696668
Primary Topic
Biomedical Text Mining and Ontologies
Type
preprint
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preprint

AION — Algebraic Interval Ontology for Clinical Networks (FM-3)

Friedhelm Matten
Zenodo (CERN European Organization for Nuclear Research)
Biomedical Text Mining and Ontologies
preprint

AION — Algebraic Interval Ontology for Clinical Networks (FM-3)

Friedhelm Matten
preprint en

Abstract

AION (Algebraic Interval Ontology for Clinical Networks) is a fully general formal mathematical model of clinical information systems, containing FM-1 as a special case and extending it in all dimensions. Extensions include: a type system with type hierarchy and schema inheritance for arbitrary clinical event types; a universal event model covering examinations, therapies, diagnoses, and observations as typed, attributed time-interval events; a complete temporal relation algebra (all 13 Allen relations); a hierarchical process model with directed acyclic graphs (DAGs); an extended formal query language with temporal quantifiers, cohort combination and multi-patient relations; a causal model with do-operator and counterfactual queries; FHIR mapping as a structural homomorphism; a formal AI layer model; and federation with Differential Privacy guarantees. The reference implementation is available as the Python package aion-clinical on PyPI. NOT a medical device (EU MDR 2017/745 / MPDG). Version 1.2 corrects four findings from an external mathematical review (errata E-4–E-7): the sign in P(precedes), the distributional assumption of the probabilistic Allen relations, the second unit indicator of the contact duration, and the notation of counterfactual queries. In addition: a formal m-nearest-neighbour definition of the matching operator, heuristic labelling of the Shapley back-propagation, and an NP-hardness note on sufficient explanations. Lizenz: Dieses Dokument steht unter AGPL-3.0-only. Alternativ ist eine kommerzielle Lizenzierung durch die ISCaD GmbH auf Anfrage über [email protected] verfügbar. Version 1.3: Lizenz-Restfundstellen (nun durchgängig AGPL-3.0-only) und Software-URL (fm2-project/cairn → iscad/aion) korrigiert, Erratum E-8. Keine inhaltliche Änderung.

Zenodo (CERN European Organization for Nuclear Research)
Instituto Superior de Ciências da Administração (PT), ISCA Technologies (United States) (US)
Peace, Justice and strong institutions
Biomedical Text Mining and Ontologies
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