High-Intensity Interval Training Snacks Improve Experimental Autoimmune Encephalomyelitis

Several studies have shown that physical activity is associated with increased life expectancy and the prevention of chronic and neurodegenerative diseases. This study aimed to evaluate the impact of high-intensity interval training (HIIT) on the progression of an experimental model of multiple sclerosis. For this purpose, the murine model of experimental encephalomyelitis (EAE) was used in female C57BL/6 mice, divided into four groups: negative control (CN), positive control (EAE), HIIT once a day (1-HIIT), and HIIT snacks, three times a day (3-HIIT). The clinical score results demonstrated a significant reduction in the clinical score in mice subjected to 3-HIIT, confirmed by analyses of pro- and anti-inflammatory cytokines and histological analyses. These results provided solid evidence for the potential of HIIT protocols, especially 3-HIIT, to reprogram an autoimmune response in the CNS in mice with the EAE model, favoring a neuroprotective and immunoregulatory environment—evidence that may drive clinical research.