Exploratory Multi-Modal Assessment of Water Thermographic Dynamics and Autonomic Responses to a 52° Geometric Configuration: Cross-Session Reproducibility, Neuro-Computational Digital Twin Modeling, and Contextual Comparison with 58° and Electroencep

Description This exploratory study presents a multi-modal framework for investigating the biophysical and physiological effects associated with exposure to a 52° geometric configuration. The work integrates infrared thermography (IRT) of water, facial skin, and blood samples with photoplethysmography (PPG) measurements to examine thermal dynamics and autonomic cardiovascular responses across independent experimental sessions. To assess reproducibility, experiments were performed on three separate days, with one session excluded following predefined quality-control criteria due to signal acquisition and file integrity issues. Despite substantial variability in the thermographic behavior of water between valid sessions, autonomic responses demonstrated consistent directional changes, including reduced heart rate, increased RMSSD, and decreased pulse amplitude. The study further introduces an exploratory neuro-computational Digital Twin (Version 18.0) based on Leaky Integrate-and-Fire neurons, Hebbian synaptic plasticity, and simplified neurotransmitter kinetics to generate hypothesis-driven mappings between peripheral autonomic signals and predicted cognitive states. Model outputs are interpreted as normalized computational indices rather than direct physiological measurements. Finally, the findings are contextually compared with a previous 58° geometric configuration study and with independent electroencephalographic (EEG) data reported in a doctoral thesis. This comparison suggests that the 52° configuration may be associated with a distinct physiological profile characterized by strong parasympathetic activation together with computationally predicted alert relaxation. The study is intended as a hypothesis-generating proof-of-concept and provides a reproducible analytical workflow for future larger-scale, sham-controlled, and multimodal investigations into potential geometric-biological interactions.