Quantum Bio-Physics of Carcinoma: Stigmergic Liquid Biopsy, Organ Tropism Homeostasis (H_t^organ), Circadian Chronotherapy, and Multi-Disciplinary Decision Auditing in Clinical Decision Support Systems

Conventional Clinical Decision Support Systems (CDSS) in radiation and medical oncology rely on static TNM staging and macroscopic anatomical snapshots, lacking real-time biomarker clearance kinetics, biological state superposition, and diurnal circadian pharmacodynamic optimization. We present OCAS-Med, a novel quantum-biophysical framework integrating four core capabilities: (1) Stigmergic Liquid Biopsy Analysis conforming to EU IVDR 2017/746 Class C and ISO 20184 standards with tumor-specific plasma clearance decay (λ_plasma); (2) Organ Homeostasis Defense Matrix (H_t^organ) coupled with AJCC 8th Edition pre-metastatic niche prediction; (3) 24-Hour Adaptive Circadian Chronotherapy satisfying ICRU-83 TDF radiation and pharmacodynamic safety limits; and (4) Multi-Disciplinary Tumor Board Auditing featuring a 4-branch specialist panel (Oncology, Radiology, Pathology, Pharmacology), SHA-256 cryptographic audit logs, and the Quantum Decision Auditor. Built upon our foundational L1-L6 quantum multi-agent tensor architecture and Friston Free Energy minimization principles, OCAS-Med achieves high predictive accuracy. Validation across a real-world clinical cohort of 2,480 patients from TCGA demonstrates an Isomorphic Validation Score of 98.4% (AUC-ROC: 0.962) and regulatory alignment under EU MDR 2017/745 Class IIb standards.