Clinical variations and outcomes of central serous chorioretinopathy in Black and White patients: MICRoN report-16

PURPOSE: To compare baseline characteristics and outcomes of central serous chorioretinopathy (CSCR) between people who identify as Black and those who identify as White. METHODS: This retrospective, multicenter study from the MICRoN study group, included Black and White patients with CSCR. Demographic information and multimodal imaging parameters were analyzed and compared in the two groups. Regression models were used to identify factors affecting visual outcomes, anatomical changes, and disease recurrence/persistence. RESULTS: We included a total of 450 patients (312 males and 138 females), of whom 100 were Black patients, and 350 were White patients. Black patients were significantly older (51.9 versus 48.8 years, p=0.03) but had shorter symptom duration at presentation (1 versus 3 months, p=0.003). They demonstrated worse baseline visual acuity (0.3±0.3 versus 0.2±0.2 logMAR, p<0.001), greater retinal detachment height (157.9 versus 107.5 μm, p=0.002), and more frequent peripapillary retinal pigment epithelium changes (27% versus 9.4%, p<0.001). During a median follow-up of 24 months (IQR 10 to 60 months), White patients experienced significantly higher rates of disease recurrence (35.7% versus 19%, p=0.002), persistent subretinal fluid (13.1% versus 4%, p=0.01), and macular neovascularization development (21.1% versus 4%, p<0.001). Multivariable regression confirmed that Black patients were associated with reduced recurrence risk (OR 0.52, p=0.03). CONCLUSIONS: Despite presenting with more severe morphological changes and worse initial vision, Black patients demonstrate substantially lower rates of recurrences and sequelae, suggesting biological differences in disease pathophysiology.

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Journal
Retina
Published
2026-07-30
DOI
https://doi.org/10.1097/iae.0000000000004949
Primary Topic
Retinal Diseases and Treatments
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article
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article

Clinical variations and outcomes of central serous chorioretinopathy in Black and White patients: MICRoN report-16

Halit Winter, Bita Momenaei, Stela Vujosevic, Elizabeth Rossin et al.
Retina
Retinal Diseases and Treatments
article

Clinical variations and outcomes of central serous chorioretinopathy in Black and White patients: MICRoN report-16

Halit Winter, Bita Momenaei, Stela Vujosevic, Elizabeth Rossin, Elodie Bousquet, Andrea Coletto, Felicia Hertkorn, Yusuf Ashfaq, Luiz H. de Lima, Luis Arias Barquet, Kent Small, MOHAMED EL BARKANI, Roselind Ni, Jay Wang, Marion R. Munk, Glenn Yiu, Rufino Silva, Carol Villafuerte-Trisolini, Giulia Gregori, Marco Lupidi, Sunir Garg, Lorenzo Ferro Desideri, Maurizio Battaglia Parodi, Carmen Antía Rodríguez-Fernández, Jay Chhablani, Nasiq Hasan, Panisa Singhanetr, Priya Shah, Lihteh Wu, Manjot K. Gill, Rahul N. Khurana, Gabriele Piccoli, Zachary Kroeger, Charles C. Wykoff, Niroj Kumar Sahoo, Adrian T. Fung, Jessica Cao
article en

Abstract

PURPOSE: To compare baseline characteristics and outcomes of central serous chorioretinopathy (CSCR) between people who identify as Black and those who identify as White. METHODS: This retrospective, multicenter study from the MICRoN study group, included Black and White patients with CSCR. Demographic information and multimodal imaging parameters were analyzed and compared in the two groups. Regression models were used to identify factors affecting visual outcomes, anatomical changes, and disease recurrence/persistence. RESULTS: We included a total of 450 patients (312 males and 138 females), of whom 100 were Black patients, and 350 were White patients. Black patients were significantly older (51.9 versus 48.8 years, p=0.03) but had shorter symptom duration at presentation (1 versus 3 months, p=0.003). They demonstrated worse baseline visual acuity (0.3±0.3 versus 0.2±0.2 logMAR, p<0.001), greater retinal detachment height (157.9 versus 107.5 μm, p=0.002), and more frequent peripapillary retinal pigment epithelium changes (27% versus 9.4%, p<0.001). During a median follow-up of 24 months (IQR 10 to 60 months), White patients experienced significantly higher rates of disease recurrence (35.7% versus 19%, p=0.002), persistent subretinal fluid (13.1% versus 4%, p=0.01), and macular neovascularization development (21.1% versus 4%, p<0.001). Multivariable regression confirmed that Black patients were associated with reduced recurrence risk (OR 0.52, p=0.03). CONCLUSIONS: Despite presenting with more severe morphological changes and worse initial vision, Black patients demonstrate substantially lower rates of recurrences and sequelae, suggesting biological differences in disease pathophysiology.

Retina
Northwestern University (US), Marche Polytechnic University (IT), Massachusetts Eye and Ear Infirmary (US), The University of Sydney (AU), Vita-Salute San Raffaele University (IT), Sun Yat-sen University (CN), Oregon Health & Science University (US), University of Pittsburgh (US), University of Milan (IT), Université Paris Cité (FR), University Hospital of Bern (CH), Hospitais da Universidade de Coimbra (PT), Bellvitge University Hospital (ES), Westmead Hospital (AU), Macula and Retina Institute (US), Retina Consultants of Texas (US), MultiMedica (IT), Ministerio de Agricultura y Ganadería de Costa Rica (CR), Hôpital Lariboisière (FR), University of Pittsburgh Medical Center (US), Association for Innovation and Biomedical Research on Light and Image (PT), Istituti di Ricovero e Cura a Carattere Scientifico (IT), Retina Vitreous Associates of Florida (US), Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT), Glendale Community College (US), University of Coimbra (PT), University of California, Davis (US), Wills Eye Hospital (US), Universidade Federal de São Paulo (BR), Macquarie University (AU)
Openalex Percentile: Top 7%
Retinal Diseases and Treatments
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