The Alternative Complement Pathway in IgA Nephropathy: A Podcast for Advanced Practice Providers

Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide and contributes considerably to the global burden of chronic kidney disease, with up to 50% of patients' disease progressing to kidney failure within 10-20 years of diagnosis. The pathogenesis of IgAN is driven by the deposition of immune complexes containing galactose-deficient immunoglobulin A1 in the glomeruli of the kidney. This deposition activates downstream inflammatory pathways, including the alternative complement pathway, leading to progressive glomerular injury. In this podcast article, a nephrologist and two advanced practice providers discuss the clinical features and pathogenesis of IgAN and explore the importance and clinical implications of alternative complement pathway overactivation in IgAN. The authors also discuss the evolving therapeutic landscape and provide their future perspectives on therapies targeting the underlying disease pathogenesis, including complement inhibitors, as well as the remaining gaps in patient care. PODCAST CONTENT: The podcast video can be downloaded from the article's Figshare page here: https://doi.org/10.6084/m9.figshare.32587806 . Alternatively, you can stream the podcast by searching for 'Adis Journal Podcasts' on your preferred podcast platform. Supplementary file 1 (MP4 225123 kb).