Optimising combination therapy for paediatric, adolescent and young adult patients with non-rhabdomyosarcoma soft tissue sarcomas: The OCTOPUS platform trial
Few innovative treatments were developed for patients with non-rhabdomyosarcoma soft tissue sarcomas (NRSTS) in the past decades. The paper describes the OCTOPUS project (Optimising Combination Therapy fOr Paediatric, adolescent and yoUng adult patients with non-rhabdomyosarcoma soft tissue Sarcomas), a master protocol and includes an adaptive platform trial comprising different sub-trials, a real-world data registry, translational studies, and overarching study questions assessing local therapy issues and patient reported outcome measures (PROMs). The OCTOPUS consortium will provide an operational framework including a legal consortium structure, a network of national coordinating centres (NCCs) and sites within the EpSSG (European paediatric Soft tissue sarcoma Study Group) and ITCC (Innovative Therapies for Children and adolescents with Cancer) network. The overarching aim of the platform is to improve outcome and quality of life for patients with NRSTS by providing access to innovative treatments. Every sub-trial will have a unique design, tailored to the needs of the patients, the characteristics of the disease, and the stage of development of the experimental compound(s). Depending on the medical need in a specific patient population and the expected activity of a compound (or a combination), the innovative treatment(s) will be offered to patients with relapsed/refractory disease or placed in frontline treatment when appropriate.
Authors
- Nadège Corradini (ORCID: https://orcid.org/0000-0002-1942-1222)
- Michela Casanova (ORCID: https://orcid.org/0000-0003-0368-7883)
- Alwin D. R. Huitema (ORCID: https://orcid.org/0000-0003-1939-4639)
- Shushan Hovsepyan (ORCID: https://orcid.org/0000-0002-7367-6752)
- Max M. van Noesel (ORCID: https://orcid.org/0000-0003-0503-5838)
- Harm van Tinteren (ORCID: https://orcid.org/0000-0002-4626-8702)
- Nicole Scobie (ORCID: https://orcid.org/0000-0002-6539-2741)
- Michael T. Meister (ORCID: https://orcid.org/0000-0001-8311-721X)
- Kelly L.A. van Bindsbergen (ORCID: https://orcid.org/0000-0001-5158-7444)
- Daniela Di Carlo (ORCID: https://orcid.org/0000-0003-0573-8576)
- Lucy Métayer (ORCID: https://orcid.org/0000-0001-6682-5847)
- Andrea C. Ferrari (ORCID: https://orcid.org/0000-0002-4724-0517)
- Walter Ferrari Bravo
- Willemijn Breunis
- Martha Grootenhuis
- Gabriela Guillén Burrieza
- Sheila Terwisscha van Scheltinga
- Reineke A. Schoot
- Daniel Orbach
- David Riedl
- Raquel Davila Fajardo
- Bernadette Brennan
- Daria Valerio
Institutions
- University of Padua (IT)
- University of Milan (IT)
- Utrecht University (NL)
- Université Paris Sciences et Lettres (FR)
- Institut Gustave Roussy (FR)
- University Medical Center Utrecht (NL)
- Centre Léon Bérard (FR)
- Oncode Institute (NL)
- Princess Máxima Center (NL)
- Vall d'Hebron Hospital Universitari (ES)
- University Children's Hospital Zurich (CH)
- Ludwig Boltzmann Institute for Cancer Research (AT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Royal Manchester Children's Hospital (GB)
- University Hospital Innsbruck (AT)
- Ludwig Boltzmann Institute for Digital Health and Prevention (AT)
Publication Details
- Journal
- Tumori Journal
- Published
- 2026-07-30
- DOI
- https://doi.org/10.1177/03008916261456574
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00