<scp>DU</scp> ‐Vigilance; Capturing Unsuspected Problems in Drug Utilization

Key Points Pharmacovigilance should expand beyond adverse drug reactions. A concept, Drug Utilization Vigilance (DU‐vigilance), is proposed as an approach to detect unsuspected prescribing or utilization problems. DU‐vigilance relies on analyses of large‐scale real‐world data. Aberrant drug utilization is dynamic and requires continuous surveillance. Integrating DU‐vigilance within traditional pharmacovigilance could improve healthcare quality.