Molecular velcro for precision genome repair
Base editing promises transformative therapies for genetic disease, but delivery constraints have limited clinical translation. Mu and colleagues show that programmable coiled-coil assembly can create highly efficient split base editors and demonstrate its in vivo functionality.
Authors
- Roman Jerala (ORCID: https://orcid.org/0000-0002-6337-5251)
- Duško Lainšček (ORCID: https://orcid.org/0000-0001-9613-5441)
Institutions
- National Institute of Biology (SI)
- National Institute of Chemistry (SI)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-07-28
- DOI
- https://doi.org/10.1038/s41467-026-76136-9
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00