Nanoparticles In Cancer Drug Delivery: Recent Advances, Therapeutic Applications And Challenges

Abstract : Cancer is one of the major causes of Mortality around the world, Despite Having significant advances in diagnosis and treatment. Conventional therapeutic-based approaches such as chemotherapy, radiotherapy, and surgeries are often limited due to poor selectivity, Toxicity, inadequate accumulation of drugs at tumor sites, and development of resistance to multi-drugs. Nanotechnology has developed as a better platform for improving Cancer treatment through the development of Nanoparticle based System of drug delivery. These nanoparticles have unique Physical and chemical properties that include It’s nano scale size, Large surface area and its characteristics, enhanced drug-loaded capacity and controlled release of the drugs. These kind of properties helps to fight cancer cells by minimising damage to the healthy tissues. Various kinds of nanoparticles, Such as dendrimers, metallic nanoparticles, liposomes, and hybrid nano carriers, result in better therapeutic Outcomes in preclinical and clinical studies. Recent advancements Which include Smart Nanoparticles, gene delivery systems, Immunotherapy based Nanomedicines and environment responsive drug delivery systems for tumors, Etc. These nanoparticle-based therapies have a better potential for multi-drug resistance and enhance the treatment efficiency. Despite having these advancements, there are also some challenges Which includes toxicity, Biological effects, Manufacturing And regulatory approval. This affects its widespread use for clinical treatments. This review therefore summarizes the recent developments, therapeutic applications, challenges, and future perspectives of Nanoparticle based cancer drug delivery systems.