SUBDERMAL BIFUNCTIONAL INSULIN DELIVERY IMPLANT UTILIZING A SMART PBA HYDROGEL BODY AND A SELF-SEALING SILICONE REFILL CAP

This document details the architectural specification and numerical validation for project SUB-RESP-DIABETES-2026, a long-term, non-electronic subdermal implant engineered for automated glycemic regulation in Type-1 Diabetes. The primary body is constructed from a biocompatible polymer integrated with a glucose-responsive Phenylboronic Acid (PBA) Hydrogel, paired with a self-sealing medical-grade silicone dome for percutaneous micro-needle refills. Features a 24-hour dynamic kinetic simulation, mass transfer equations, and bio-integration frameworks (Zwitterionic PCBMA + VEGF angiogenic matrix).

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-07-28
DOI
https://doi.org/10.5281/zenodo.21645630
Primary Topic
Diabetes Management and Research
Type
preprint
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preprint

SUBDERMAL BIFUNCTIONAL INSULIN DELIVERY IMPLANT UTILIZING A SMART PBA HYDROGEL BODY AND A SELF-SEALING SILICONE REFILL CAP

Mohammed Hussein Mohamed Mohammed Rashad
Zenodo (CERN European Organization for Nuclear Research)
Diabetes Management and Research
preprint

SUBDERMAL BIFUNCTIONAL INSULIN DELIVERY IMPLANT UTILIZING A SMART PBA HYDROGEL BODY AND A SELF-SEALING SILICONE REFILL CAP

Mohammed Hussein Mohamed Mohammed Rashad
preprint en

Abstract

This document details the architectural specification and numerical validation for project SUB-RESP-DIABETES-2026, a long-term, non-electronic subdermal implant engineered for automated glycemic regulation in Type-1 Diabetes. The primary body is constructed from a biocompatible polymer integrated with a glucose-responsive Phenylboronic Acid (PBA) Hydrogel, paired with a self-sealing medical-grade silicone dome for percutaneous micro-needle refills. Features a 24-hour dynamic kinetic simulation, mass transfer equations, and bio-integration frameworks (Zwitterionic PCBMA + VEGF angiogenic matrix).

Zenodo (CERN European Organization for Nuclear Research)
Diabetes Management and Research
DOIOpen Access PDFOpenAlex
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SUBDERMAL BIFUNCTIONAL INSULIN DELIVERY IMPLANT UTILIZING A SMART PBA HYDROGEL BODY AND A SELF-SEALING SILICONE REFILL CAP — Mohammed Hussein Mohamed Mohammed Rashad · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS