Systemic Inflammation and Outcomes After Mitral Edge‐to‐Edge Repair: Insights From the OCEAN‐Mitral Registry

BACKGROUND: Systemic inflammation is increasingly recognized as an important contributor to cardiovascular outcomes. High-sensitivity CRP (C-reactive protein) is an established biomarker, but its prognostic value after mitral transcatheter edge-to-edge repair remains unclear. Clinical parameters such as body temperature may also reflect systemic inflammation; however, their prognostic role in this setting is uncertain. We sought to investigate the association between baseline inflammation makers and long-term outcomes in patients undergoing mitral transcatheter edge-to-edge repair. METHODS: We analyzed 3511 patients from the OCEAN (Optimized Catheter Valvular Intervention)-Mitral registry with available CRP, categorized by Centers for Disease Control and Prevention/American Heart Association cutoffs: <1.0 mg/L (n=1216), 1.0-3.0 mg/L (n=988), and >3.0 mg/L (n=1307). Body temperature was also assessed as an exploratory inflammatory marker. RESULTS: During a median follow-up of 13 (interquartile range, 10-26) months, 826 deaths and 911 composite event of cardiovascular death or hospitalization for heart failure were observed. In multivariable models, both CRP and body temperature were associated with higher risk of death (CRP: hazard ratio [HR], 1.98 [95% CI, 1.63-2.40]; and body temperature: HR, 1.49 [95% CI, 1.25-1.78]). Patients with both elevated CRP (>3.0 mg/L) and high temperature (≥37.0 °C) had the highest risk. Sequential Cox analyses showed an incremental value of CRP beyond clinical, laboratory, and echocardiographic variables. The prognostic effect was most pronounced in patients without preprocedural inotrope use. CONCLUSIONS: Elevated CRP is an independent and incremental predictor of death and heart failure outcomes after mitral transcatheter edge-to-edge repair, with its prognostic impact amplified by higher body temperature. These findings highlight the importance of incorporating systemic inflammation into risk stratification for structural heart interventions. REGISTRATION: URL: https://www.umin.ac.jp/ctr/; Unique identifier: UMIN-ID: UMIN000023653.

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Journal
Journal of the American Heart Association
Published
2026-07-28
DOI
https://doi.org/10.1161/jaha.125.048726
Primary Topic
Cardiac Valve Diseases and Treatments
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article
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article

Systemic Inflammation and Outcomes After Mitral Edge‐to‐Edge Repair: Insights From the OCEAN‐Mitral Registry

Mike Saji, Hiroshi Ueno, Masahiko Asami, Yohei Ohno et al.
Journal of the American Heart Association
Cardiac Valve Diseases and Treatments
article

Systemic Inflammation and Outcomes After Mitral Edge‐to‐Edge Repair: Insights From the OCEAN‐Mitral Registry

Mike Saji, Hiroshi Ueno, Masahiko Asami, Yohei Ohno, Yusuke Watanabe, Masanori Yamamoto, Kentaro Hayashida, Hisao Otsuki, Toshiaki Otsuka, Kazunori Omote, Yusuke Enta, Atsushi Sugiura, Gaku Nakazawa, Makoto Amaki, Daisuke Hachinohe, Masaki Izumo, Shinichi Shirai, Shunsuke Kubo, Yuki Izumi, Kazuhisa Kodama, OCEAN‐Mitral investigators, Shingo Mizuno, Hiroki Bota, Masahiro Yamawaki, Tetsuro Shimura, Toru Naganuma
article en

Abstract

BACKGROUND: Systemic inflammation is increasingly recognized as an important contributor to cardiovascular outcomes. High-sensitivity CRP (C-reactive protein) is an established biomarker, but its prognostic value after mitral transcatheter edge-to-edge repair remains unclear. Clinical parameters such as body temperature may also reflect systemic inflammation; however, their prognostic role in this setting is uncertain. We sought to investigate the association between baseline inflammation makers and long-term outcomes in patients undergoing mitral transcatheter edge-to-edge repair. METHODS: We analyzed 3511 patients from the OCEAN (Optimized Catheter Valvular Intervention)-Mitral registry with available CRP, categorized by Centers for Disease Control and Prevention/American Heart Association cutoffs: <1.0 mg/L (n=1216), 1.0-3.0 mg/L (n=988), and >3.0 mg/L (n=1307). Body temperature was also assessed as an exploratory inflammatory marker. RESULTS: During a median follow-up of 13 (interquartile range, 10-26) months, 826 deaths and 911 composite event of cardiovascular death or hospitalization for heart failure were observed. In multivariable models, both CRP and body temperature were associated with higher risk of death (CRP: hazard ratio [HR], 1.98 [95% CI, 1.63-2.40]; and body temperature: HR, 1.49 [95% CI, 1.25-1.78]). Patients with both elevated CRP (>3.0 mg/L) and high temperature (≥37.0 °C) had the highest risk. Sequential Cox analyses showed an incremental value of CRP beyond clinical, laboratory, and echocardiographic variables. The prognostic effect was most pronounced in patients without preprocedural inotrope use. CONCLUSIONS: Elevated CRP is an independent and incremental predictor of death and heart failure outcomes after mitral transcatheter edge-to-edge repair, with its prognostic impact amplified by higher body temperature. These findings highlight the importance of incorporating systemic inflammation into risk stratification for structural heart interventions. REGISTRATION: URL: https://www.umin.ac.jp/ctr/; Unique identifier: UMIN-ID: UMIN000023653.

Journal of the American Heart Association
Toho University (JP), Tokai University (JP), St. Marianna University School of Medicine (JP), Keio University (JP), Kurashiki Central Hospital (JP), Sapporo Higashi Tokushukai Hospital (JP), New Tokyo Hospital (JP), Saiseikai Kumamoto Hospital (JP), Sapporo Science Center (JP), Cardiovascular Center Hokkaido Ohno Hospital (JP), National Cerebral and Cardiovascular Center (JP), Toyohashi Heart Center (JP), Sakakibara Hospital (JP), Mitsui Memorial Hospital (JP), Toyama University Hospital (JP), Nagoya Heart Center (JP), Shonan Kamakura General Hospital (JP), Saiseikai Yokohama Eastern Hospital (JP), Gifu Heart Center (JP), Kokura Memorial Hospital (JP), Nippon Medical School (JP), Teikyo University (JP), Kindai University (JP)
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