Cup‐Like Nuclei Is a Hallmark of <i>DUX4/ERG</i> Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation
ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Authors
- Élodie Lainey (ORCID: https://orcid.org/0000-0002-0224-4338)
- Hélène Cavé (ORCID: https://orcid.org/0000-0003-2840-1511)
- Marion Strullu (ORCID: https://orcid.org/0000-0002-9229-0150)
- Chloé Arfeuille (ORCID: https://orcid.org/0000-0002-9345-4268)
- Yoann Vial (ORCID: https://orcid.org/0000-0003-1437-0427)
- Odile Fenneteau
- Aurélie Caye‐Eude (ORCID: https://orcid.org/0000-0001-5996-3037)
- Alexia Kinoo
- André Baruchel
- Hugo Roux
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Institut Gustave Roussy (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Robert-Debré (FR)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2026-07-28
- DOI
- https://doi.org/10.1002/1545-5017.70422
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00