DIG-MambaNet: A Dual-Path Interactive Guided Mamba Network for Medical Image Segmentation

Reliable medical image segmentation remains challenging because models must preserve fine boundary details while maintaining global semantic consistency. CNNs capture local structures effectively but have limited long-range modeling ability, whereas Transformer-based methods improve global context at high computational cost. Mamba-based state space models offer efficient long-range modeling, but may weaken high-frequency textures and boundary cues. To address these limitations, we propose DIG-MambaNet, a Dual-path Interactive Guided Mamba Network for medical image segmentation. The network introduces a dual-path complementary modeling block (DCM Block), where a cross-feature spatial interaction module (CSIM) adaptively integrates CNN-based local features and Mamba-based global features. A source image-guided module (SIGM) injects high-frequency information from the original image to compensate for downsampling-induced detail loss, while an inter-layer detail refinement fusion module (IDRFM) improves encoder–decoder feature alignment during reconstruction. Experiments on 2018DSB, ISIC2018, JSUAH-Cerebellum, and CVC-ClinicDB, covering nuclei segmentation in microscopy images, skin lesion segmentation in dermoscopic images, fetal cerebellum segmentation in ultrasound images, and polyp segmentation in colonoscopy images, demonstrate that DIG-MambaNet achieves consistent and competitive performance across diverse target structures and imaging conditions, with improved boundary delineation and favorable overlap-based accuracy compared with representative CNN-, Transformer-, and Mamba-based methods.