Identification of a New, Potent, and Stable Tetrahydroquinoline-Based 5-LOX/sEH Dual Inhibitor with Polymodal Anti-Inflammatory Activity in Acute Pancreatitis
as a promising anti-inflammatory agent supporting dual 5-LOX/sEH inhibition, coupled with Nrf2 activation, as a viable strategy for AP.
Authors
- Tania Ciaglia (ORCID: https://orcid.org/0000-0002-6592-4373)
- Ornella Ricci (ORCID: https://orcid.org/0000-0001-6853-471X)
- Danilo D’Avino (ORCID: https://orcid.org/0000-0002-6350-5191)
- Giovanna Aquino (ORCID: https://orcid.org/0000-0001-5457-1712)
- Anna Di Dio
- Giovanni Ferrara (ORCID: https://orcid.org/0009-0008-8531-4944)
- Carmine Ostacolo (ORCID: https://orcid.org/0000-0003-3715-8680)
- Simone Di Micco (ORCID: https://orcid.org/0000-0002-4688-1080)
- Antonietta Rossi (ORCID: https://orcid.org/0000-0002-3237-2584)
- Francesca Di Matteo (ORCID: https://orcid.org/0000-0002-9907-6472)
- Manuela Giovanna Basilicata (ORCID: https://orcid.org/0000-0003-2736-1044)
- Veronica Di Sarno (ORCID: https://orcid.org/0000-0002-1397-5240)
- Giuseppe Bifulco (ORCID: https://orcid.org/0000-0002-1788-5170)
- Michele Manfra (ORCID: https://orcid.org/0000-0002-3320-972X)
- Oliver Werz (ORCID: https://orcid.org/0000-0002-5064-4379)
- Simona Musella (ORCID: https://orcid.org/0000-0001-8312-4241)
- Isabel Gómez‐Monterrey (ORCID: https://orcid.org/0000-0001-6688-2606)
- Giacomo Pepe (ORCID: https://orcid.org/0000-0002-7561-2023)
- Ignazio Sardo (ORCID: https://orcid.org/0009-0005-8153-0322)
- Gerardina Smaldone (ORCID: https://orcid.org/0000-0003-1380-9717)
- Fabrizio Merciai (ORCID: https://orcid.org/0000-0002-2774-4697)
- Fiorentina Roviezzo (ORCID: https://orcid.org/0000-0003-1582-7396)
- Alessia Bertamino (ORCID: https://orcid.org/0000-0002-5482-6276)
- Pietro Campiglia (ORCID: https://orcid.org/0000-0002-1069-2181)
- Eduardo Sommella (ORCID: https://orcid.org/0000-0001-8654-6431)
- Valeria Napolitano (ORCID: https://orcid.org/0000-0003-2328-2824)
- Rosario Stimoli
- Paul Jordan
- Sara Perna (ORCID: https://orcid.org/0009-0001-6438-9137)
- Sofia Pellecchia
Institutions
- University of Salerno (IT)
- University of Basilicata (IT)
- Bay Area Medical Center (US)
- Gene Therapy Laboratory (FR)
- European Biomedical Research Institute of Salerno (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- University of Naples Federico II (IT)
- Friedrich Schiller University Jena (DE)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-07-27
- DOI
- https://doi.org/10.1021/acs.jmedchem.6c01458
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Freistaat Thüringen
- European Commission
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Thüringer Aufbaubank
- Ministero dell'Istruzione e del Merito