Discovery of a Potent, Orally Bioavailable Small-Molecule Inhibitor of Wildtype KIT with Exceptionally High Kinome Selectivity

Authors

Kelsey E. Sivick
Lixia Jin (ORCID: https://orcid.org/0000-0001-8018-9779)
Matthew J. Walters (ORCID: https://orcid.org/0000-0003-4419-5949)
Guillaume Mata (ORCID: https://orcid.org/0000-0001-8064-8699)
Anne M. van Abbema
Hyunyoung Moon
Jay P. Powers (ORCID: https://orcid.org/0000-0002-0355-2551)
Jenna L. Jeffrey (ORCID: https://orcid.org/0000-0001-9249-5984)
Xuelei Yan (ORCID: https://orcid.org/0000-0001-5966-8775)
Manmohan R. Leleti (8962166)
Nigel P. Walker (8682108)
Patrick G. Schweickert
Stephen W. Young
Hsin-Ting Huang
Xiaoning Zhao
Karen Y. Chen
David W. Green
Jiang Zhu
Shiwei Qu
Manjunath Lamani
Zhang Wang

Publication Details

Journal: Journal of Medicinal Chemistry
Published: 2026-07-26
DOI: https://doi.org/10.1021/acs.jmedchem.6c00898
Primary Topic: Mast cells and histamine
Type: article
Field-Weighted Citation Impact: 0.00

Discovery of a Potent, Orally Bioavailable Small-Molecule Inhibitor of Wildtype KIT with Exceptionally High Kinome Selectivity

Kelsey E. Sivick, Lixia Jin, Matthew J. Walters, Guillaume Mata, Anne M. van Abbema, Hyunyoung Moon, Jay P. Powers, Jenna L. Jeffrey, Xuelei Yan, Manmohan R. Leleti (8962166), Nigel P. Walker (8682108), Patrick G. Schweickert, Stephen W. Young, Hsin-Ting Huang, Xiaoning Zhao, Karen Y. Chen, David W. Green, Jiang Zhu, Shiwei Qu, Manjunath Lamani, Zhang Wang

July 26, 2026article en

Discovery of a Potent, Orally Bioavailable Small-Molecule Inhibitor of Wildtype KIT with Exceptionally High Kinome Selectivity

Authors

Publication Details

Discovery of a Potent, Orally Bioavailable Small-Molecule Inhibitor of Wildtype KIT with Exceptionally High Kinome Selectivity

Discovery of a Potent, Orally Bioavailable Small-Molecule Inhibitor of Wildtype KIT with Exceptionally High Kinome Selectivity

Abstract

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