Gastric carcinoma in a 25-year-old man with Fanconi anemia: case report and literature review

Fanconi anemia (FA) is a rare genetic disorder characterized by defective DNA repair, genomic instability, and bone marrow failure.It affects approximately 1 in 200,000 live births and increases the risk of malignancies, including solid tumors.We report a 25-year-old man with FA who presented severe weight loss, vomiting, and oral intolerance.Imaging revealed pyloric stenosis and gastric wall thickening.Endoscopy confirmed intramucosal intestinal-type gastric adenocarcinoma.Despite hematologic optimization, chemotherapy, and total gastrectomy, the patient died from severe malnutrition.Early surveillance and multidisciplinary management are essential to improve outcomes in patients with FA.