Formal Hydride Abstraction: A Unified Photoredox Platform for Nucleophilic C(sp <sup>3</sup> )–H Functionalization
-benzyl azoles. Finally, we discuss our deep mechanistic interrogation of C-H sulfonamidation, where the identification and suppression of a parasitic proton-coupled electron transfer (PCET) pathway proved essential for catalytic efficiency.Collectively, these studies demonstrate that with the correct polarity-inversion machinery, C-H bonds can be viewed not merely as radical precursors, but as latent carbocations ready to engage in the full spectrum of polar reactivity.
Authors
- Patricia Zhang Musacchio (ORCID: https://orcid.org/0000-0002-0211-1893)
- James (1833 - 1911) Mortimer
Institutions
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- Accounts of Chemical Research
- Published
- 2026-07-27
- DOI
- https://doi.org/10.1021/acs.accounts.6c00378
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University at Buffalo
- National Institute of General Medical Sciences