Radiosynthesis and Preclinical Evaluation of Enantiopure ( <i>R</i> )-[ <sup>18</sup> F]Fluorolactate for PET Imaging of Metabolic Processes
F]Fluorolactate is a metabolically stable, MCT1-sensitive PET tracer suitable for noninvasive assessment of lactate transport and metabolism and shows promise for imaging MCT1-dependent lactate transport in cancer.
Authors
- Heidi Liljenbäck (ORCID: https://orcid.org/0000-0001-9372-1584)
- Pyry Dillemuth (ORCID: https://orcid.org/0000-0002-4210-6781)
- Mitra Gerami
- Anne Roivainen (ORCID: https://orcid.org/0000-0002-4006-7977)
- Aino Latva‐Rasku (ORCID: https://orcid.org/0000-0001-8786-9160)
- Xiang‐Guo Li (ORCID: https://orcid.org/0000-0002-9118-7223)
- Pirjo Nuutila (ORCID: https://orcid.org/0000-0001-9597-338X)
- Johan Rajander (ORCID: https://orcid.org/0000-0003-3591-0963)
- Maxwell W. G. Miner (ORCID: https://orcid.org/0000-0002-3192-5722)
- Tiina A. Salminen (ORCID: https://orcid.org/0000-0002-4135-8020)
- Jenni Virta (ORCID: https://orcid.org/0000-0003-1062-8187)
- Tomi T. Airenne (ORCID: https://orcid.org/0000-0001-9645-8670)
- Xiaoqing Zhuang (ORCID: https://orcid.org/0000-0001-8652-8540)
- Jesse Ponkamo
- Sven ENERBÄCK
- Nea Läpinen
- Negar A. Samani (ORCID: https://orcid.org/0009-0003-8036-8808)
Institutions
- Åbo Akademi University (FI)
- Florida Department of Health (US)
- University of Turku (FI)
- Turku University Hospital (FI)
- Turku PET Centre (FI)
- Institute for Biomedicine (IT)
- University of Gothenburg (SE)
Publication Details
- Journal
- Molecular Pharmaceutics
- Published
- 2026-07-26
- DOI
- https://doi.org/10.1021/acs.molpharmaceut.6c00236
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00