Chiral Phosphoric Acid-Catalyzed Asymmetric Hydrogenolysis of C–O Bonds
CBD) analogs. Preliminary mechanistic experiments and DFT calculations suggested that asymmetric hydrogenolysis proceeded via an enantioselective 1,4-transfer hydrogenation initiation step, followed by an aromatization-driven remote proton transfer and skeletal rearrangement.
Authors
- Rong‐Zhen Liao (ORCID: https://orcid.org/0000-0002-8989-6928)
- Qing‐Xian Xie
- Gao‐Wei Wang
- X J Li
- Jinli Chen (ORCID: https://orcid.org/0000-0001-6359-1926)
- Chang‐Bin Yu (ORCID: https://orcid.org/0000-0003-0247-9740)
- Yong‐Gui Zhou (ORCID: https://orcid.org/0000-0002-3321-5521)
Institutions
- Dalian Institute of Chemical Physics (CN)
- Chinese Academy of Sciences (CN)
- University of Chinese Academy of Sciences (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2026-07-27
- DOI
- https://doi.org/10.1021/jacs.6c11054
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Dalian Institute of Chemical Physics
- National Key Research and Development Program of China