Discovery of Novel Anethole Trithione Derivatives Targeting SQR Pathway to Induce Mitochondrial Uncoupling for Stroke Treatment
represents a promising lead compound for stroke therapy based on a novel mechanism, warranting further development.
Authors
- Yu Zhou (ORCID: https://orcid.org/0000-0002-7684-2939)
- Xiaohan Song (ORCID: https://orcid.org/0000-0002-2135-3089)
- He Huang (ORCID: https://orcid.org/0000-0001-6998-8131)
- Hong Shu Liu (ORCID: https://orcid.org/0000-0003-3685-6268)
- Zhenwei Zhang (ORCID: https://orcid.org/0000-0003-1521-5728)
- Xuelian Ren (ORCID: https://orcid.org/0000-0002-6429-9609)
- D D Zhang
- J N Cheng
- X M Yan
- Yuan Li
- Lu Zhang
- Peng Song
- Yaqin Pei
- Yibing Wang
Institutions
- Xinjiang Medical University (CN)
- Chinese Academy of Sciences (CN)
- Soochow University (CN)
- Shanghai Institute of Materia Medica (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Drug Discovery Laboratory (Norway) (NO)
- Institute for Advanced Study (DE)
- Food and Drug Administration (TH)
- State Key Laboratory of Chemical Engineering (CN)
- Neurological Surgery (US)
- University of Chinese Academy of Sciences (CN)
- Ocean University of China (CN)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-07-26
- DOI
- https://doi.org/10.1021/acs.jmedchem.6c01057
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00