Hand Lesions as a Diagnostic Clue in Unexplained <scp>SIADH</scp>
In apparently idiopathic syndrome of inappropriate antidiuretic hormone secretion (SIADH), chilblain-like hand plaques may reveal autoimmune connective tissue disease. Skin examination, biopsy, and serology can uncover discoid lupus erythematosus with Sjögren's syndrome overlap. Serum sodium improvement after skin treatment requires caution because spontaneous stabilization cannot be excluded.
Authors
- Taiki Sugimoto (ORCID: https://orcid.org/0000-0002-6418-0755)
- Mariko Shimono
- Jun Matsumoto (ORCID: https://orcid.org/0000-0001-7224-108X)
- Zenzo Isogai (ORCID: https://orcid.org/0000-0003-3579-3680)
- Takahiro Kamihara (ORCID: https://orcid.org/0000-0003-4592-4170)
- Takuya Omura (ORCID: https://orcid.org/0000-0001-5490-8653)
- Masaki Hasegawa
- Tomomi Omura
- Nobuko Watanabe
Institutions
- Meitetsu Hospital (JP)
- National Center for Geriatrics and Gerontology (JP)
- Nagoya University (JP)
Publication Details
- Journal
- Clinical Case Reports
- Published
- 2026-07-27
- DOI
- https://doi.org/10.1002/ccr3.73237
- Primary Topic
- Electrolyte and hormonal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Center for Geriatrics and Gerontology
- Japan Society for the Promotion of Science