Metabolic Reprogramming of the Liver by IL-33: A Protective Response to Acute Injury

Background and Aims: The glucose metabolism pattern of the liver is closely related to liver diseases. In recent years, alcoholic hepatitis, viral hepatitis, fatty liver and other diseases have become important liver diseases that impact people’s lives. IL-33 (interleukin-33), as a member of the IL-1 cytokine family, and “alarmin” play a multi-dimensional regulatory role in various physiological and pathological processes of the liver. Methods: This study, by integrating transcriptomic data analysis and in vitro and in vivo experiments, expounds on new insights into the regulation of hepatocyte fate by IL-33 through metabolic reprogramming and reveals the potential, new role of IL-33 as a regulatory factor of metabolism. Conclusions: Our research further confirmed that IL-33, in addition to serving as an alarm hormone, is also a key checkpoint for liver metabolism, capable of promoting oxidative phosphorylation in hepatocytes and antagonizing acute liver injury induced by CCl4.