Enantioselective Construction of Spirocyclohexadienones Via NHC-Catalyzed Formal [5 + 1] Annulation Reaction of Dienals
-transfer and tautomerization as the key catalytic process and enable facile access to various spirocyclohexadienone-fused 2-sulfonamidoindolines, giving the spirocyclic products in moderate to excellent yields with good to excellent enantioselectivities. These procedures may provide alternative synthetic strategy for the enrichment of spirooxindoles.
Authors
- X Q Peng
- Guangcan Xu
- Xueling Meng (ORCID: https://orcid.org/0009-0009-8887-6122)
- Ningning Zan (ORCID: https://orcid.org/0000-0003-2416-7713)
- Gang Yu
- Piaopiao Zhang
- Bixue Xu
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-07-26
- DOI
- https://doi.org/10.1021/acs.orglett.6c02791
- Primary Topic
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00