Carboxylation of Heteroarenes with Carbon Dioxide under Polysulfide Anion Photocatalysis
) in aqueous dimethyl sulfoxide (DMSO) under irradiation with visible light. The process demonstrates redox-neutral carboxylation of a heteroaromatic C-H bond in a regioselective manner. Mechanistically, the reaction is likely initiated by the generation of heteroarene radical anions through single-electron reduction of heteroarenes, followed by carboxylation and oxidative rearomatization to liberate heteroarene carboxylic acids.
Authors
- Shunsuke Chiba (ORCID: https://orcid.org/0000-0003-2039-023X)
- María González‐Esguevillas (ORCID: https://orcid.org/0000-0003-3779-5516)
- Amirah S. Mat Lani (ORCID: https://orcid.org/0009-0001-1015-7963)
- Philipp C. Roosen
- Taku Wakabayashi (ORCID: https://orcid.org/0000-0002-2083-3590)
- David F. Fernández (ORCID: https://orcid.org/0000-0003-3482-0894)
- Hui Ling Saw
Institutions
- Nanyang Technological University (SG)
- Pfizer (United States) (US)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-07-26
- DOI
- https://doi.org/10.1021/acs.orglett.6c02881
- Primary Topic
- Carbon dioxide utilization in catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00