Discovery and Engineering of a Plant Glycosyltransferase for Efficient Benzylisoquinoline Alkaloid Glycosylation
) demonstrated superior antitumor activity compared to its aglycone through stronger proliferation inhibition and apoptosis induction. This work provides an efficient enzymatic toolkit for green BIA glycoside synthesis and identifies promising candidates for drug development.
Authors
- Jun Song (ORCID: https://orcid.org/0000-0002-7689-1722)
- Lu Jin (ORCID: https://orcid.org/0000-0003-2934-0271)
- Pan Shen (ORCID: https://orcid.org/0000-0001-8529-3727)
- 曹艳
- Juan Li (ORCID: https://orcid.org/0000-0002-9838-0990)
- Liang Han (ORCID: https://orcid.org/0000-0001-6213-4432)
- He Qy
- Yanling Chen (ORCID: https://orcid.org/0000-0002-6975-915X)
- Wei Huang (ORCID: https://orcid.org/0009-0005-4519-910X)
- Shihan Li (ORCID: https://orcid.org/0000-0003-3207-7064)
- Li Y
- Shijuan Wu (ORCID: https://orcid.org/0009-0009-4394-6430)
- Yutong Qin
- Yaqi Liu
Institutions
- Landscape Institute (GB)
- Hubei University of Chinese Medicine (CN)
- Korea Health Industry Development Institute (KR)
- County Hospital (GB)
- China Academy of Chinese Medical Sciences (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Northwest A&F University (CN)
Publication Details
- Journal
- Journal of Agricultural and Food Chemistry
- Published
- 2026-07-27
- DOI
- https://doi.org/10.1021/acs.jafc.6c07405
- Primary Topic
- Carbohydrate Chemistry and Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province