Approach to Geminal Bisperoxides from Aldehydes via BR <sub>3</sub> /O <sub>2</sub> -Enabled Peroxidation
-enabled peroxidation of aldehydes for the selective synthesis of geminal bisperoxides is reported. A range of geminal bisperoxides was obtained in high yields (up to >99%) from simple precursors. The synthetic utility was demonstrated through their diverse transformations into azidoperoxides, cyanoperoxides, peroxyesters, esters, and carboxylic acids. Mechanistic studies support the involvement of a radical pathway.
Authors
- Do Hyun Ryu (ORCID: https://orcid.org/0000-0001-7615-4661)
- T. SEO (ORCID: https://orcid.org/0009-0009-5152-2048)
- Gyoungho Noh
Institutions
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-07-26
- DOI
- https://doi.org/10.1021/acs.orglett.6c02563
- Primary Topic
- Oxidative Organic Chemistry Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00