Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations
As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference. Complete tumor resection is the cornerstone of treatment, with meticulous attention to preventing tumor spillage. Risk stratification of adjuvant chemotherapy decisions incorporates tumor stage and critical parameters, including histological differentiation and mitotic rate. Optimal patient management requires treatment within cooperative networks providing centralized histopathological review and comprehensive genetic testing, multidisciplinary tumor board evaluation, and prospective registry enrollment to advance knowledge for these exceptionally rare malignancies.
Authors
- Yves Réguerre (ORCID: https://orcid.org/0000-0001-7192-046X)
- Michaela Kuhlen (ORCID: https://orcid.org/0000-0003-4577-0503)
- Ines B. Brecht (ORCID: https://orcid.org/0000-0001-7973-3300)
- Calogero Virgone (ORCID: https://orcid.org/0000-0002-3651-9416)
- ANDREA FERRARI
- Gianni Bisogno (ORCID: https://orcid.org/0000-0003-4462-5523)
- Ewa Bień (ORCID: https://orcid.org/0000-0002-2091-2686)
- Michael Abele (ORCID: https://orcid.org/0000-0002-9780-603X)
- Malgorzata A. Krawczyk
- Schneider DT
- Maja Cesen (ORCID: https://orcid.org/0000-0003-2434-8960)
- Daniel Orbach
- Tal Ben‐Ami
- Kris‐Ann Schultz
- Nora Schnitzler
- Ricardo Lopez‐Almaraz
Institutions
- Children’s Minnesota - St. Paul Hospital (US)
- University of Padua (IT)
- Witten/Herdecke University (DE)
- University of Augsburg (DE)
- Université Paris Sciences et Lettres (FR)
- Kaplan Medical Center (IL)
- Ljubljana University Medical Centre (SI)
- Centre Hospitalier Universitaire de La Réunion (RE)
- University Children's Hospital Tübingen (DE)
- Klinikum Dortmund (DE)
- Hospital de Cruces (ES)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Gdańsk Medical University (PL)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2026-07-27
- DOI
- https://doi.org/10.1002/1545-5017.70571
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Société Française de lutte contre les Cancers et les leucémies de l'Enfant et de l'Adolescent
- European Commission
- Deutsche Kinderkrebsstiftung